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Metixene hydrochloride hydrate

🥰Excellent
Catalog No. TQ0304Cas No. 7081-40-5

Metixene hydrochloride hydrate has potential anticholinergic activity and inhibits the binding of quinine ring benzoate (QNB) to muscarine receptors, with IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used to prevent and treat Parkinson's disease.

Metixene hydrochloride hydrate
Other Forms of Metixene hydrochloride hydrate:

Metixene hydrochloride hydrate

🥰Excellent
Purity: 99.88%
Catalog No. TQ0304Cas No. 7081-40-5
Metixene hydrochloride hydrate has potential anticholinergic activity and inhibits the binding of quinine ring benzoate (QNB) to muscarine receptors, with IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used to prevent and treat Parkinson's disease.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$33-In Stock
25 mg$68-In Stock
50 mg$107-In Stock
100 mg$173-In Stock
1 mL x 10 mM (in DMSO)$37-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.88%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Metixene hydrochloride hydrate has potential anticholinergic activity and inhibits the binding of quinine ring benzoate (QNB) to muscarine receptors, with IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene hydrochloride hydrate can be used to prevent and treat Parkinson's disease.
Targets&IC50
mAChR:55 nM, mAChR:15 nM (Ki)
In vitro
Metixene hydrochloride hydrate, with IC50 and Ki values of 55 nM and 15 nM, respectively, has the potential to inhibit the binding of QNB with the muscarinic receptor [1].
Chemical Properties
Molecular Weight363.95
FormulaC20H26ClNOS
Cas No.7081-40-5
SmilesO.Cl.CN1CCCC(CC2c3ccccc3Sc3ccccc23)C1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 5 mg/mL (13.74c), Sonication is recommended.
DMSO: 70 mg/mL (192.34 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.5 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7476 mL13.7382 mL27.4763 mL137.3815 mL
5 mM0.5495 mL2.7476 mL5.4953 mL27.4763 mL
10 mM0.2748 mL1.3738 mL2.7476 mL13.7382 mL
20 mM0.1374 mL0.6869 mL1.3738 mL6.8691 mL
50 mM0.0550 mL0.2748 mL0.5495 mL2.7476 mL
100 mM0.0275 mL0.1374 mL0.2748 mL1.3738 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Metixene hydrochloride HydrateMetixene hydrochloride hydratemAChRCholinergic
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